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For a man,
benign prostatic hyperplasia (BPH) is a more inevitable part of
the aging process than gray hair. When a man reaches his mid-20s,
his prostate embarks on a second period of growth, and continues
to enlarge for most of the rest of his life.
While benign
means "non-cancerous," and while BPH usually does not
affect sexual function, the prostate -- as it enlarges -- presses
against the bladder and urethra, cutting down the flow of urine.
A gland that
started out in adult life the size of a walnut may, by age 40,
have grown to the size of an apricot, and by age 60, it might
be as large as a lemon. More than half of all men in their 60s
and as many as 90 percent in their 70s and 80s have some symptoms
of BPH.
While the
symptoms of BPH vary, the most common ones are problems with urination.
These include:
- A hesitant,
interrupted, weak stream;
- Urgency
and leaking or dribbling;
- More frequent
urination, especially at night.
But the problems
posed by prostate enlargement vary in severity from one man to
another. While BPH cannot be cured, early symptoms will not necessarily
grow more severe, or may worsen very slowly. Only about half the
men with enlarged prostates will develop symptoms bothersome enough
to seek medical treatment.
Men whose
symptoms are mild often opt for an approach called "watchful
waiting." The U.S. Public Health Service Clinical Practice
Guidelines call watchful waiting "an appropriate treatment
strategy for the majority of patients."
If the condition
begins to pose a danger to the patient's health or causes a major
inconvenience to him, treatment is then recommended. For those
men for whom "watchful waiting" is not enough, drugs
or surgery can help.
BPH Drug
Therapy
Millions of
American men in the last decade have chosen drug therapy over
surgery for BPH. Drugs are regarded as less effective than surgery,
but are also less invasive and generally free of major side effects.
Two major
classes of drugs are used to treat BPH: alpha adrenergic blockers
and finasteride.
Alpha adrenergic
blockers, originally used for the treatment of high blood pressure,
relax the muscular portion of the prostate and the bladder neck,
allowing urine to flow more freely. In the average patient, these
drugs increase the rate of urine flow and reduce symptoms, often
within days.
Finasteride
shrinks the prostate by blocking an enzyme that converts the male
hormone testosterone into a more potent, growth-stimulating form.
Some doctors
think that combining the two types of drugs may produce optimum
results.
BPH Surgery
Although prostate
surgery has diminished in the decade since drug therapy became
available, operations for BPH remain the most common surgery performed
on American men. Several types of surgery can relieve BPH symptoms:
They are:
Transurethral
Resection of the Prostate (TURP). A slim fiberoptic tube is
inserted through the penis and up the urethra as far as the prostate.
Using either a tiny blade or an electric loop, the surgeon pares
away the urethras lining and bits of excess prostate tissue, expanding
the passageway is expanded. TURF typically doubles the urinary
flow within weeks.
Transurethral
Incision of the Prostate (TUIP). An instrument is inserted
through the penis to reach the prostate, but the surgeon makes
only one or two small cuts to relieve pressure in the prostate
rather than trimming away tissue. Like TURP, the procedure considerably
increases the urine flow.
Transurethral
Needle Ablation (TUNA). A catheter is inserted into the uretha
that deploys needles toward the obstructing prostate tissue. Radio
frequency energy is then delivered through needles to kill excess
prostate tissue.
Open Prostatectomy.
A surgeon makes an incision through either the lower abdomen
or the perineum to reach the prostate, instead of inserting an
instrument through the urethra. This procedure is used only on
extremely large prostates.
The best approach
for treating BPH is not clear. The U.S. Public Health Service
Clinical Practice Guidelines advise doctors to leave treatment
decisions to the patient, after a discussion of the benefits and
side effects of each treatment option.
Having BPH
does not seem to increase the chances of getting prostate cancer.
Nevertheless, a man who has BPH may have undetected prostate cancer
at the same time or may develop prostate cancer in the future.
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